We’re not talking about the Smurfs or the aliens in Avatar. People really can be born with skin pigmentation that makes them look blue. In fact, it is the result of a congenital methemoglobinemia in people who are Caucasian. People with this condition have an abnormally high amount of methemoglobin in their blood that actually causes the blood to look brown and the skin to look blue. This disorder also causes red blood sells to supply less oxygen to the tissues than normal, so sufferers will have shortness of breath, become dizzy easily and their mental status may be unstable.